Glucophage generic name is gliquinone tablets, which belongs to the short-acting agonists that promote insulin secretion. Baisupine generic name is acarbose, belongs to the α-glucosidase inhibitor. They are two kinds of hypoglycemic drugs with different hypoglycemic mechanism, adverse effects and contraindications. 1. Glargizone tablets can bind to pancreatic β-cells and lower blood glucose levels by promoting insulin release. Gliquidone is not metabolized by the kidneys and can be used in renal insufficiency. It is a commonly used short-acting insulinotropic agent for elderly diabetic patients. Adverse reactions to the drug include skin irritation, hypoglycemia, and gastrointestinal reactions. Type 1 diabetes, diabetic coma or pre-coma, diabetes combined with acidosis or ketosis, allergic to sulfonamides, pregnancy, lactation and advanced uremia patients are prohibited. 2. Acarbose can inhibit the intestinal absorption of glucose, thereby reducing postprandial blood glucose. Acarbose can cause gastrointestinal adverse reactions such as nausea and vomiting. The drug should not be used in people with gastrointestinal dysfunction, pregnant women, lactating women and children. Gliquidone Tablets and Acarbose can be used alone or in combination, and the sugar-lowering effect will be more pronounced after the joint use, but the medication needs to follow the doctor’s instructions, and blood glucose levels need to be closely monitored during the use of the medication.