Tetanus bacillus is an anaerobic bacterium, which means that it is more suitable for growth in an oxygen-poor environment. Therefore, generally tetanus infected wounds are deep and dirty wounds, such as wounds stabbed by nails or sharp objects, which are not only poorly cleaned but also deeper, which will easily lead to internal hypoxia, which is conducive to the growth and infection of tetanus bacillus. Therefore, in addition to debridement, dressing change and anti-inflammatory treatment, tetanus antitoxin should also be injected into deep and dirty wounds to prevent tetanus bacillus infection. Generally wound infection with tetanus bacillus will lead to muscle spasm and tonic contraction. Paralysis will occur in later stages, seriously endangering people’s lives. Tetanus prophylaxis should do skin test when injecting, and for positive patients, multiple desensitization injections should be taken to play tetanus prophylaxis.