Small cell type osteosarcoma is one of the types of osteosarcoma, and treatment includes surgery, chemotherapy, radiation therapy, and medication. Osteosarcoma is a kind of malignant tumor, which is mostly found in adolescents and manifests as bone and joint pain as well as localized lumps. 1. Surgery: Surgery is the main treatment of osteosarcoma at present, including amputation and limb preservation surgery. Maximize the resection of the lesion and preserve the function. 2.. Chemotherapy: it is divided into preoperative chemotherapy and postoperative chemotherapy. Preoperative chemotherapy can determine the sensitivity of the tumor to chemotherapy and can effectively eliminate metastatic lesions and improve the survival rate. Postoperative chemotherapy can kill small metastatic foci and delay the appearance of metastatic foci. 3. Radiotherapy: it is aimed at areas that cannot be surgically removed such as pelvis, skull base, etc., poor response to chemotherapy, and pathological fracture. 4. Drug therapy: mainly used for analgesia, such as aspirin, tramadol, pethidine and so on. The medication should follow the principles of stepwise medication, on-time medication, preferred oral medication and personalization. All of the above medications should be taken under the guidance of a medical professional. The treatment of small cell osteosarcoma should follow the principle of “early detection, early diagnosis, early treatment” to avoid delaying the best time for treatment.