Common peroneal nerve entrapment syndrome can be cured. Patients may choose conservative treatment or surgery depending on their individual situation. Common peroneal nerve entrapment syndrome is caused by the compression of the common peroneal nerve and its branches, causing a series of sensory disorders, dysfunction and other symptoms. The disease can be seen in peroneal head fracture, foot inversion injury, long-term sitting on the knees, bone giant cell tumor and so on. Early stage of the disease can be relieved by applying anti-inflammatory and analgesic drugs, such as ibuprofen, acetaminophen and other drugs, which are prohibited for pregnant and lactating women. Patients can also choose corrective braces to achieve immobilization, which can prevent ankle sprains. If the effect of medication is not satisfactory, it is recommended to carry out peroneal nerve release surgery, after which the patient’s pain and sensory loss can be significantly improved. The medication needs to be taken under the guidance of a doctor, and it is recommended that the patient should have a review on time, and if there is any adverse reaction, go to the hospital in time for a follow-up consultation and treatment under the guidance of a doctor.