The skin long cauliflower-like bumps may be acromegaly, epidermal nevus, filiform warts and other diseases, need to take medication, physical therapy, surgical treatment for the cause of the disease. 1. Condyloma acuminatum: patients need to follow the doctor’s instructions to use 5% imiquimod cream, 0.5% onychomycetin cream and other drugs, as well as 80% ~ 90% trichloroacetic acid solution. It can also be treated by physical measures such as microwave therapy and electrocoagulation. For patients with fewer lesions, or the above treatments are not effective, surgical treatments such as high-frequency electrocautery, shearing and scraping need to be considered. 2. Epidermal nevus: patients need to use retinoic acid ointment, adapalene gel and other retinoic acid drugs, as well as 5-fluorouracil ointment, and dexamethasone, prednisone and other glucocorticosteroids under the guidance of doctors. Liquid nitrogen freezing, carbon dioxide laser and other physical therapy can also be taken, for only a small area of damage to the patient, surgical excision can be taken. 3. filiform warts: patients need to follow the doctor’s instructions for external use of 10% ~ 26% salicylic acid ointment, 5% imiquimod cream, 0.1% ~ 0.3% vinblastine alcohol solution, 3% phthalamide cream and other drugs for intractable warts, need to cooperate with the doctor to use 1% procaine diluted with pingyangmycin injected in the wart body. Some patients can follow the doctor’s instructions to use interferon, levamisole and other immunomodulation. This disease can also be treated by physical measures such as freezing, electrocautery, and scraping if the skin lesions are small. It is recommended that the skin long cauliflower-shaped bumps timely to the hospital, a clear diagnosis, as soon as possible to cooperate with the doctor for standardized treatment, to strengthen the daily life management, so as not to delay the condition.