Anti-streptococcal hemolysin “O” as high as 600 IU/ml is usually serious, but its severity varies depending on the condition. Anti-streptococcal hemolysin “O” is the antibody produced by the human body after being infected by streptococcus A. Streptococcal A infection is closely related to rheumatic fever, acute glomerulonephritis, scarlet fever, acute tonsillitis, etc. Anti-streptococcal hemolysin “O” up to 600IU/ml is an obvious abnormal result, which is usually more serious. ” as high as 600IU/ml belongs to the obvious abnormal results, usually more serious. Patients should further improve CRP, blood sedimentation, autoantibodies and other related auxiliary examinations and combine with the patient’s signs, symptoms and other factors to clarify the causes of the antibody elevation and targeted to timely and standardized treatment, different diseases caused by anti-“O” elevation, the severity of the patient’s condition also exists a certain degree of difference. Patients with elevated anti-streptococcal hemolysin “O” are advised to go to the rheumatology and immunology department of regular hospitals, the infection department and other related departments for detailed consultation and treatment according to the doctor’s instructions.