Derisin is the trade name and generic name of Flupirtirtide Melitrexate. This drug is widely used in the treatment of depression and anxiety disorders. As this drug is a compound preparation composed of two compounds, antidepressant and antipsychotic, long-term use will increase tolerance, induce mania, aggravate Parkinson’s syndrome, and cause delayed dyskinesia in severe cases. 1. Parkinson’s syndrome: the metabolism and excretion ability of the elderly is reduced, even if the use of low-dose of the product, can cause high blood concentration, this drug blocks the postsynaptic membrane low-affinity D2 receptors, long-term use of the drug is likely to lead to Parkinson’s disease, so it should be used with caution in patients with Parkinson’s disease. Serious cases can cause delayed dyskinesia. 2 induced mania: antidepressant-induced mania is the severity of tricyclic antidepressants > 5-HT and NE dual-channel inhibitors > selective 5-HT recycling inhibitors. This product is a tricyclic antidepressant, theoretically prone to induce mania, so it should be avoided in patients with bipolar disorder. The drug is used under the guidance of a physician, avoiding the blind use of medication on their own, and regular rechecks of liver and kidney function.