Patients waking up at 2 or 3 in the middle of the night can be treated with Gentian Liver Pill, Gui Spleen Pill and Liu Wei Di Huang Pill according to the clinical manifestations. 1. Longdian Diarrhea Liver Pill: When the patient wakes up at two or three o’clock in the middle of the night, accompanied by symptoms such as irritability, redness of the eyes and bitterness of the mouth, yellow and red urine, constipation and so on, it can be judged as waking up in the middle of the night caused by the liver and fire disturbing the heart, and Longdian Diarrhea Liver Pill can be taken. Gentian diarrhea liver pill has the effect of clearing the liver and gallbladder and promoting dampness and heat, the contraindications and adverse reactions of the drug are not clear, and those who are allergic to the product are forbidden to take it. 2. Gui Spleen Pill: When patients have symptoms such as waking up in the middle of the night, timidity, fearfulness, panic attacks, dizziness, palpitations (rapid heartbeat, often accompanied by panic), forgetfulness, etc., it can be judged to be caused by timidity of the heart and weakness of qi and blood, and can be taken as Gui Spleen Pill. The effects of Gui Spleen Pills are to benefit the qi and strengthen the spleen (regulating the qi of the spleen and stomach), nourish the blood and calm the mind (stabilizing the mind and soothing the emotions by nourishing the blood). The contraindications of these pills are unclear, and they may cause digestive discomfort and skin rashes in some cases. 3. Liu Wei Di Huang Wan: When patients wake up at 2 or 3 o’clock in the middle of the night, accompanied by dizziness and tinnitus, lumbar and knee soreness and weakness (a feeling of soreness and weakness in the lumbar and knee regions), hot flashes (a burst of heat), night sweating (abnormal sweating after going to sleep, but sweating stops after waking up), and five heart-quietness and heat (heat in the heart of the hands and the hearts of the feet, and self-consciousness about the heat of the heart and chest), they can take the Six-flavored Digoxigenic Pill. LIU WEI DI HUANG PILL has the efficacy of nourishing yin and tonifying the kidney, and the contraindications and adverse reactions of this drug are not clear. When patients often wake up at two or three o’clock in the middle of the night, it is recommended to pay enough attention to the need to go to the hospital in time to avoid delaying the condition.