Lipoma at the base of the thigh in combination with swelling of the lower limbs usually requires surgical intervention, which may be supplemented with drugs such as ibuprofen. Lipoma at the base of the thigh that is accompanied by lower limb edema may be due to compression of the lower limb reflux veins or lymphatic vessels by the lipoma, which may not be effectively treated with medications alone. Surgical treatment is currently the mainstay of clinical practice to remove this lipoma and treat it with medication. On the basis of surgery, medication can be used for symptomatic adjuvant treatment. For example, you can choose to take ibuprofen and other pain relieving drugs to treat the pain after surgery; take amoxicillin, cefaclor and other antibiotics to prevent infections; take grass rhinoceros infusion tablets, horse chestnut seed extract tablets and other drugs to reduce the swelling of the treatment. Ibuprofen, antibiotics and other drugs should be used under the guidance of a clinician.