High unconjugated bilirubin and total bilirubin may be caused by decreased liver function or destruction of red blood cells, etc. We should cooperate with professional doctors to improve blood routine, liver, gallbladder and spleen ultrasound, liver function, Hepatitis B 5, hepatitis markers and other tests to make a clear diagnosis, and then carry out medication in time, and consider surgical treatment if necessary. 1. Decrease in liver function: If the decrease in liver function leads to high unconjugated bilirubin and total bilirubin, the main treatment is to protect the liver and liver protection, commonly used medicines include compound glycyrrhizin tablets, liver protection tablets, liver tylenol, etc., and can also be injected with compound glycyrrhizin injection, reduced glutathione, etc., and with vitamin C tablets, to promote the recovery of liver function. 2. Erythrocyte destruction: If the destruction of red blood cells leads to high unconjugated bilirubin and total bilirubin, which may cause hemolytic anemia, glucocorticoids, immunosuppressants or androgens should be chosen for treatment, such as prednisone, cyclosporine, cyclophosphamide, danazol and so on. If medication is not effective, consider splenectomy if necessary. If non-conjugated bilirubin and total bilirubin are high, it is recommended to cooperate with the doctor as soon as possible to carry out examination and standardized treatment, the specific use of drugs, follow the doctor’s instructions. Usually, you should pay attention to rest, avoid overwork, and take a light diet, eat more fresh vegetables and fruits rich in vitamins, and avoid spicy and stimulating foods.