Spleen enlargement is not necessarily portal hypertension, spleen enlargement may also be caused by long-term alcohol consumption, acute viral hepatitis and other factors, the specific circumstances need to be judged under the guidance of a doctor. 1. Portal vein hypertension: once a patient develops portal vein hypertension, it will lead to obstruction of venous return in the spleen and poor blood circulation, thus resulting in splenomegaly. 2. Prolonged alcohol consumption: In daily life, prolonged alcohol consumption may lead to elevated aminotransferase levels, affecting liver metabolism and causing cirrhosis, resulting in the phenomenon of splenomegaly. 3. Acute viral hepatitis: when acute viral hepatitis is in the period of attack, it will cause the body to be in a state of stress and active immune response. The phenomenon of increased adaptive function and enlargement of the spleen may also occur. Spleen enlargement may also be associated with other diseases, such as chronic leukemia, malaria and so on. Once a patient develops an enlarged spleen, it is recommended to go to the hospital for further examination, make a clear diagnosis and carry out treatment under the guidance of the doctor.