Ozone (○3) is an almost colorless gas with strong special odor, extremely unstable and easily decomposed in air and human tissues. Compared with oxygen, ozone is characterized by a high specific gravity, odor, color, solubility in water, and easy decomposition. Because the ○-atoms of ozone decomposition are very active, thus ozone has a strong oxidizing ability, the effect is completed in an instant and there is no permanent residue. Ozone injection is a safe, effective, simple and economical treatment for a wide range of chronic pain. The analgesic treatment principle of ozone: 1. Oxidation of proteoglycans in the nucleus pulposus: proteoglycans, one of the main components in the nucleus pulposus, have a negative charge and can attract a positive charge to the nucleus pulposus matrix, i.e., they have the property of fixed charge density. Ozone oxidizes the nucleus pulposus, dehydrates, atrophies and coagulates the intervertebral disc, reduces the pressure of the disc and reduces the pressure on the nerve. 2, anti-inflammatory effect: the protruding nucleus pulposus and fibrous ring compress the dura mater, nerve roots and surrounding veins, causing impaired reflux, exudation and tissue edema, forming sterile inflammation. Ozone can stimulate the overexpression of oxidase, neutralize the reactive oxidation products produced in excess in the inflammatory response, antagonize the release of immune factors in the inflammatory response, dilate blood vessels, improve reflux, and reduce edema around the nerve roots. 3, analgesic effect: the protruding disc tissue can compress the nerve roots and stimulate the release of pain-causing substances (such as substance P, phospholipid plum A2, etc.) from the small intervertebral articular processes, adjacent ligaments and nerve endings present on the surface of the disc. ○3 injection can act directly on nerve endings and stimulate inhibitory interneurons to release enkephalins and other substances, thus achieving analgesic effects, which is the basis for ○3 treatment of soft tissue pain. Indications: 1.Intervertebral disc herniation, lumbar spine surgery failure syndrome. 2, soft tissue pain: various soft tissue pains, such as: myofasciitis, shoulder periarthritis, third lumbar transverse process syndrome, pear-shaped muscle syndrome, etc. 3.Arthritis: Ozone injection can treat various kinds of arthritis, frozen shoulder, ischemic necrosis of the femoral head, osteoarthritis of the knee and other complications of aseptic inflammation of the sacroiliac joint, hip and knee joint cavity. 4, neuropathic pain: such as for postherpetic neuralgia, trigeminal neuralgia, occipital neuralgia and sciatica, etc., ozone injection after radiofrequency can be used as an auxiliary treatment.