Povidone iodine suppositories vaginally administered stomach pain may be caused by drug irritation and drug interactions, need to clarify the cause of the symptomatic treatment. 1. Drug stimulation: povidone iodine suppositories vaginally administered will produce stimulation of the intestinal tract, triggering contraction of the smooth muscle of the intestinal wall, which leads to the emergence of paroxysmal abdominal pain. At the same time, if the abdomen is stimulated will lead to uterine contraction, usually manifested as a slight pulling pain or slight pain in the lower abdomen. 2. Drug interactions: if povidone iodine suppositories and alkaloids, alkaloids, phenols, sodium thiosulfate, starch, chloral hydrate, tannic acid, etc. are applied together, it will cause drug interactions, which may reduce the efficacy of the drug or cause patients to have adverse reactions such as stomach pain. If symptoms are delayed or show signs of worsening, prompt medical attention is required.