Knee bone pain is usually caused by patellar fracture, patellar tuberculosis, patellar tumor and patellar chondromalacia, etc. The pain can be treated with medication and surgery. 1. Patellar fracture: patellar fracture without displacement is generally treated by non-surgical methods. Keep the knee joint in the straight position under the plaster or brace fixation for 4~6 weeks, after fixation, muscle contraction training is needed. If there is a large displacement of the fracture, it should be treated surgically, using incision and reduction. 2. Patellar tuberculosis: systematic systemic anti-tuberculosis treatment is needed, while surgery is needed to remove the lesion completely, and postoperative braking can get better results. Common anti-tuberculosis drugs include pyrazinamide, isotretinoin, rifampicin, ethambutol, etc. It is recommended to use them under doctor’s guidance. 3. Patellar tumor: generally treated by surgery, if the pathological examination is benign, the lesion can be scraped off, if malignant, generally need to total patellar joint patellar tendon resection. 4. Chondromalacia patella: when the chondromalacia patella is mild, it can be treated with physiotherapy and hot compresses and medication, oral pain relief and anti-inflammation such as celecoxib. Serious condition can be arthroscopic minimally invasive surgery for joint cleaning and cartilage repair. There are many factors that can cause patellofemoral pain, and it is recommended to go to the hospital to find out the cause of the problem and treat it in time.