Pimples are usually referred to as acne, and the causes of acne around the mouth in boys include high androgen levels leading to overproduction of sebaceous glands, abnormal keratinization of sebaceous gland ducts in hair follicles, and proliferation of Propionibacterium acnes. 1. High androgen levels lead to excessive sebaceous gland secretion: abnormal secretion of androgens due to hereditary factors can cause sebaceous glands to secrete large amounts of sebum, resulting in acne around the mouth. 2. Abnormal keratinization of follicular sebaceous gland ducts: Due to the overgrowth of keratinized cells at the openings of the follicular sebaceous glands around the mouth, the openings become narrowed or even blocked, affecting the discharge of shed epithelial cells and sebum, which can lead to the formation of pimples. 3. Proliferation of Propionibacterium acnes: Oleophilic anaerobic Propionibacterium acnes proliferates in the blocked sebaceous glands, which can cause localized inflammatory reactions and pimples. It is recommended that male patients with acne around the mouth should go to the hospital in time to see a doctor to clarify the cause of the acne and then carry out standardized treatment under the guidance of the doctor.