Hiccups all the time normally do not require medication, but if they last for more than 48 hours may be due to certain pathological reasons, such as intracranial lesions, gastrointestinal diseases, etc., and then should be treated according to the cause of the disease. 1. Normal condition: hiccups last for a few minutes or a few hours, usually no medication is needed, and can be relieved by physical measures such as pressing the eyeballs, holding the breath and gargling ice water. 2. Pathological hiccups: hiccups may be caused by central diseases, such as intracranial infections, intracranial tumors, cerebrovascular lesions, etc. Other gastrointestinal causes such as gastroesophageal reflux disease and diaphragmatic hernia are common. After the cause of the disease is clear, the cause of the disease is removed and treated, if the cause of the disease is ineffective or the cause of the disease is unknown, omeprazole can be applied first for treatment, and if it is ineffective, then medicines such as baclofen, gabapentin, probenecid, or metoclopramide, domperidone and so on, need to be applied. If the hiccups continue to be unrelieved, it is recommended to consult a doctor to find out the cause of the disease and follow the doctor’s instructions for medication.