Blood amylase 169 U/L suggests elevated amylase, but does not meet the diagnostic criteria for acute pancreatitis. It also does not indicate the severity of the disease. The main cause of elevated amylase is acute pancreatitis, but other diseases can also cause it to rise, but the change is often not significant. When blood amylase reaches 169 U/L, the first step is to exclude the possibility of acute pancreatitis. The normal index of blood amylase is 35~135U/L, and the index of blood amylase has reached 169U/L, which exceeds the maximum range, but the diagnostic standard of acute pancreatitis is that the patient’s index can be elevated up to more than three times of the upper limit, so the diagnostic standard of acute pancreatitis has not been reached for the time being. In case of acute pancreatitis, the amylase may not be elevated to the maximum value at the initial stage, but gastrointestinal perforation, ovarian disease, intestinal obstruction, etc. can also lead to mild elevation of amylase. If acute pancreatitis is serious, it may also harm the circulatory system and respiratory system, so blood amylase 169U/L is recommended to improve the relevant laboratory tests and then standardized treatment according to the guidance of professional doctors, so as not to delay the condition and cause other complications.