Cullen’s sign is a bluish color around the umbilicus that occurs during intra-abdominal hemorrhage.In 1918, Cullen et al. reported a case of periumbilical skin color change in a patient with ruptured ectopic pregnancy hemorrhage, and the sign was later named Cullen’s sign.Cullen’s sign is most often seen in acute hemorrhagic necrotizing pancreatitis, and in addition to acute pancreatitis, it can also be seen in some diseases, such as ruptured abdominal aortic aneurysm bleeding, ruptured duodenal tumor perforation, or endometriosis in the umbilicus and other diseases. diseases such as ruptured and bleeding abdominal aortic aneurysm, ruptured and perforated duodenum, ruptured abdominal tumor, ruptured ectopic pregnancy or umbilical endometriosis. Because they can all lead to the accumulation of large amounts of blood in the abdominal cavity, they can all cause the bluish sign around the umbilicus.