Everyone knows that smoking is harmful to health, and smoking will aggravate the occurrence and development of nephritis. Because nephritis is an immune-mediated inflammatory disease, smoking will aggravate the damage to the immune system and increase the amount of urinary protein leakage significantly. Smoking will cause vasoconstriction, blood pressure rise, dizziness, headache, insomnia, vision loss, so that the risk of cerebrovascular disease increases. Smoking affects appetite leading to nutritional deficiencies and reduced resistance in nephritis patients, which is easy to be combined with infections and aggravate the condition of nephritis. Smoking increases the vasoconstriction of kidney, aggravates renal ischemia, and further aggravates the sclerotic glomerular lesions. Repeated smoking makes the glomerular lesions not easy to be repaired, and thus is not conducive to the recovery of nephritis, which will ultimately lead to the decline of glomerular filtration rate, accelerating the process of renal insufficiency, and in addition, smoking also affects the function of reproduction.