Squatting up knee pain may be caused by meniscus injury, patellofemoral arthritis, knee arthritis and other diseases, you can take medication, surgical treatment to improve. 1. Meniscus injury: If meniscus injury leads to squatting up knee pain, patients first need to rest immediately, timely ice packs to relieve pain. Patients can take oral ibuprofen, rofecoxib and other non-steroidal anti-inflammatory drugs as prescribed by the doctor to relieve pain. If the condition is serious, patients can also take surgical treatment, such as meniscus suture surgery, meniscoplasty and so on. 2. Patellofemoral arthritis: If patellofemoral arthritis causes knee pain when squatting, patients can take oral non-steroidal anti-inflammatory drugs as prescribed by the doctor, such as diclofenac sodium, celecoxib and so on. You can also inject joint lubricating fluid to inhibit cartilage degeneration, such as sodium vitrate. Serious disease can also take surgical treatment, such as patellofemoral joint cleaning, patellofemoral joint replacement. 3. Knee osteoarthritis: squatting up knee pain may be caused by knee osteoarthritis, the patient can follow the doctor’s instructions oral non-steroidal anti-inflammatory drug treatment, such as piroxicam, meloxicam and so on. If the effect of drug treatment is not good, you can also take surgical treatment, such as knee joint cleaning, osteotomy orthopedics or knee replacement. There are many reasons that lead to knee pain when squatting up, it is recommended that the patient is to seek medical attention to clarify the cause of the disease and then standardize the treatment.