Craniotomy is a powerful stimulus for the brain caused by trauma, which can cause a significant increase in the brain’s demand for nutrients, so there will be a compensatory lack of oxygen supply to the brain, causing yawning. At the same time, post-surgical pain can cause psychological tension and anxiety, which is also another important cause of yawning after surgery, attention should be paid to relaxation, while pain medication such as ibuprofen can be used appropriately to relieve symptoms.