Mucosal lesions around the duodenal papilla are usually associated with inflammation, ulceration, and carcinoma, and can be treated conservatively or surgically depending on the cause. 1. Inflammation: e.g. duodenal papillitis, for inflammatory lesions, anti-inflammatory treatment can be carried out by oral antibiotics, e.g. ceftazidime, penicillin, azithromycin. 2. ulcers: for example, duodenal ulcers, when the condition is serious, it will lead to mucosal ulceration, the treatment of the disease need to take oral drugs to promote mucosal healing drugs, such as aluminum sulfate, aluminum hydroxide, and so on. Those with gastric acid reaction can take oral proton pump inhibitors, such as omeprazole, lansoprazole and so on. When causing hemorrhage, minimally invasive surgery should be performed in time. 3. Cancer: mainly refers to duodenal cancer, which is a kind of malignant tumor and can be removed by surgery in time for early stage. If the cancer cells have metastasized or spread and cannot meet the conditions of surgery, radiotherapy should be carried out in time to inhibit the cancer cells. It is recommended to consult the doctor as soon as possible for lesions in the mucous membrane around the nipple and analyze the cause by endoscopy, ultrasonography and gastrointestinal angiography according to the instruction of the doctor, and then take regular treatment according to the doctor’s suggestion.