The furrows on both sides of the nose are called nasolabial folds and are symmetrical facial anatomical landmarks. The nasolabial folds are composed of a series of muscles that are innervated by the facial nerve. When the facial nerve becomes diseased, it can lead to impaired movement of the innervated facial muscles, resulting in the shallowing or disappearance of the nasolabial folds. It is most commonly seen in peripheral facial palsy, where the facial nerve is invaded, causing facial nerve edema or compression by a tumor. If the facial palsy is caused by a viral infection, antiviral treatment such as intravenous ribavirin, hormone therapy such as dexamethasone drip, and nerve-nourishing drugs such as methylcobalamin can be given. If it is caused by tumor compression, surgery is needed to remove the tumor compression on the facial nerve to cure facial palsy.