In patients who have undergone cholecystectomy, the degree of aging is not directly related to whether the gallbladder was removed or not. If a patient after laparoscopic cholecystectomy or open cholecystectomy has symptoms related to weight loss, weakness and poor appetite within a short period of time. First of all, pathological examination should be done after surgery to determine whether gallbladder stones and cholecystitis are present. If this is the case, it is recommended to actively investigate the systemic digestive system to determine whether there are functional or organic diseases of the digestive system, and to observe whether atrophic gastritis, colitis, and proctitis are present. If there is any of the above organic diseases, treatment should be given accordingly, and if necessary, appropriate oral medications for intestinal flora regulation and gastrointestinal dysfunction regulation, such as Jin Shuangqi capsule, trimebutine maleate capsule and other medications should be actively treated. In addition, if patients consider the possibility of recent weight loss, it is recommended to do PET-CT examination if necessary to observe whether there is a possibility of tumor diseases in other parts of the body.