I. Diagnosis consistent with Parkinson’s disease 1. Decreased movement:The speed of initiating random movements is slow. The speed and amplitude of repetitive movements are reduced after disease progression. 2. At least the following features are present: muscle rigidity; resting tremor of 4-6 Hz; postural instability (not caused by primary visual, vestibular, cerebellar and proprioceptive dysfunction. Second, three or more of the following features must be present to support the diagnosis of Parkinson’s disease 1. unilateral onset; 2. resting tremor; 3. gradual progression; 4. persistent asymmetric involvement after onset; 5. good response to levodopa treatment (70% to 100%); 6. severe heterokinesia due to levodopa; 7. levodopa treatment effect lasting 5 years or more; 8, The clinical course of the disease is 10 years or more. The following signs and symptoms do not support Parkinson’s disease and may be Parkinson’s superimposed on Parkinson’s syndrome. History of recurrent stroke episodes with a stepwise progression characteristic of Parkinson’s disease; 2. History of recurrent brain injury; 3. History of definite encephalitis and/or non-drug induced oculogyric crisis; 4. Application of antipsychotics and/or dopamine depleting drugs at the time of symptom onset; 5. More than 1 relative with the disease; 6, Persistent remission or rapid progression of the disease; 9. Failure to treat with high doses of levodopa (except for absorption disorders); 10. Strictly unilateral involvement 3 years after onset; 11. Other neurological signs and symptoms, such as vertical gaze palsy, ataxia, early severe autonomic involvement, early severe dementia with memory, speech and executive dysfunction, positive pyramidal fasciculus sign The disease is characterized by severe autonomic involvement at an early stage, severe dementia with memory, speech and executive functions, positive pyramidal signs, etc.