A burst of fever in the calves may be strenuous exercise, varicose veins of the lower extremities, diabetic peripheral neuropathy, cellulitis, chronic osteomyelitis and other factors, need to address the cause of the treatment. 1. Strenuous exercise: sprinting, long-distance running, high jump, long jump, weight lifting and other strenuous exercise, the calf muscle cells anaerobic respiration produces a lot of lactic acid, so the calves will be a burst of fever. Reasonable rest and relaxation of muscles can be restored. 2. Varicose veins of the lower limbs: long time standing and other factors lead to the weakness of the vein wall of the lower limbs, the veins are tortuous, dilated and the venous blood is stagnant, so there will be a burst of fever in the calves. It can be treated with Mazolin, Diosmin tablets or surgery. 3. Diabetic peripheral neuropathy: long-term high blood sugar causes peripheral neuropathy, resulting in neurosensory dysfunction and symptoms. It can be treated with glucose-lowering drugs such as metformin, dagliflozin, glipizide or subcutaneous insulin injection. 4. Cellulitis: trauma, infection and other causes of subcutaneous connective tissue septic inflammatory lesions in the calf, local redness, swelling and heat pain. It can be treated with antibacterial drugs such as ceftazidime, piperacillin, doxycycline and amikacin. 5. Chronic osteomyelitis: bone marrow infection in the lower limbs causes inflammatory lesions in the bone marrow, resulting in localized fever, swelling and pain. It can be treated with penicillin, vancomycin, meropenem and other antibacterial drugs or surgical treatment. Pay attention to the use of drugs under the guidance of physicians.