1.A lifetime anticoagulation is required after mechanical flap replacement and 6 months after biological flap replacement; anticoagulation therapy generally uses oral warfarin. 2, currently common warfarin is divided into imported and domestic formulations, imported formulations of 3 mg per tablet dose, domestic models usually 2.5 mg per tablet. 3, during anticoagulation therapy, the prothrombin time needs to be regularly rechecked, the results will give the international normalized ratio (INR), according to the international standardized ratio to adjust the warfarin dose. Anticoagulation target values (INR): mechanical mitral valve 1.8-2.2 mechanical aortic valve 1.6-2.0 mechanical tricuspid valve 2.5-3.0 biological valve 1.5 Warfarin takes 2-3 days to take full effect, and the prothrombin time checked on the same day reflects the efficacy of oral warfarin taken 2-3 days ago. Warfarin sodium will reach a stable blood level about 7-14 days after administration. increase the warfarin dose if the INR is lower than the target value, and conversely, decrease the warfarin dose if the INR is higher than the target value. Please consult your doctor for specific adjustments. If you adjust the dose or change the dosage form, please pay attention to recheck the prothrombin time until the INR is stable within the target value. 4, during the period of taking warfarin, do not eat a lot of vitamin K-rich foods or drugs, vitamin K-rich foods include leeks, carrots, spinach, tomatoes, animal liver; vitamin K-rich drugs include multivitamins, some blood tonic drugs (application requires consultation with the doctor). 5, avoid bumping and other injuries in life. If you find nose bleeding, bleeding from brushing teeth, or large bruises on the skin after bumping, you should go to the local hospital and have your coagulation function rechecked in time to avoid drug overdose. And inform your doctor that you are taking warfarin sodium for valve replacement to avoid delays. If you need other surgery, you should also inform your doctor that you are taking warfarin sodium for heart valve replacement surgery. 6.If you need to take other drugs, please read the drug instructions in detail to know if there is any effect on warfarin.