In adrenocortical hyperplasia, it is necessary to clarify unilateral, bilateral and pituitary lesions to decide the treatment.1. Check the pituitary MRI. For patients with combined pituitary tumors, bilateral adrenocortical hyperplasia may occur. At this time, adrenal gland disease alone cannot be treated, and treatment is needed for pituitary gland disease, and adrenocortical hyperplasia can be relieved after getting rid of pituitary gland etiology. 2. Unilateral adrenocortical hyperplasia is seen only in simple adrenal hyperplasia or cortical tumors. Cortical tumors usually secrete glucocorticoids, salt corticoids and sex hormones. It is necessary to check the adrenal cortical hormone series to clarify what kind of hormone is elevated. If it is elevated salt corticosteroids, it will manifest as elevated aldosterone and can be treated with oral spironolactone if there is no obvious tumor in the early stage. If it is elevated sex hormones and elevated glucocorticoids, a thin-section CT of the adrenal glands is required to check for microscopic adenomas of the cortex. If a sebaceous adenoma is present, surgical removal is required. If the hormone level is normal and no sebaceous adenoma is seen in the adrenal gland, it can be reviewed periodically for observation.