There are many reasons for swelling, mainly due to the following factors: first, disease swelling, heart disease, liver disease, kidney disease and endocrine disease may lead to generalized swelling or localized swelling. Second, idiopathic swelling, in which women aged 20-40 years old may have mild swelling of the eyelids and face and sunken edema of the lower limbs after waking up, is related to neuropsychiatric factors and autonomic dysfunction. Third, reactive puffiness, the patient’s body is fat and inactive, affected by the hot environment, the skin blood vessels will diffuse, body fluids will penetrate and gather under the skin, and a puffy reaction will occur. Fourth, drug-related swelling, many drugs can lead to swelling, such as adrenocorticosteroids, androgens, testosterone, insulin can lead to swelling. The above-mentioned are the causes of swelling in patients, and it is recommended that patients go to a regular hospital for relevant examinations to clarify the diagnosis.