The involuntary shaking of the thumb may be seen in the following situations: 1, Parkinson’s disease: mainly seen in the elderly over 60 years of age, is a neurodegenerative disease, manifested by tremor of the limbs, slow movement, abnormal muscle tone, posture and gait abnormalities, and some patients can appear involuntary shaking of the thumb phenomenon. 2, idiopathic tremor: it is a kind of unknown cause of the onset of the tremor, tremor-based neurological disorders, patients do not have increased muscle tone and movement delay. 3, extrapyramidal diseases: mainly seen in some cerebrovascular diseases, tumors, encephalitis and so on, the sequelae of extrapyramidal disorders. Idiopathic tremor: it is a kind of neurological disease with unknown cause, mainly caused by tremor, and there is no increase in muscle tone and slow movement. 3. Extrapyramidal disease: it is mainly seen in some cerebrovascular diseases, tumors, encephalitis, etc. The sequelae of extrapyramidal disease are involuntary movement, which manifests as involuntary shaking of thumbs and so on.