Irinotecan adverse reactions mainly include diarrhea and neutropenia, which can be discontinued or treated with medication in time for the discomfort. 1. Diarrhea: it is a common adverse reaction of this drug, which appears around the 5th day after taking the drug, often manifested as watery discharge, and can be treated with loperamide under the guidance of doctors. If the symptoms are not relieved after 48 hours, it is necessary to take quinolone drugs, such as nalidixic acid and moxifloxacin, and so on, for treatment. 2. Neutropenia: It is often accompanied by symptoms of stomach discomfort, such as nausea, vomiting, etc. When the symptoms are serious, drugs such as fexofenadine and sargramostim can be taken for treatment. Irinotecan should be used under the guidance of a doctor, to avoid the use of private medication, discomfort symptoms, most can be relieved after stopping the drug, if not relieved need to consult a doctor in time to take treatment.