The second toe cramp, the specific situation is as follows: 1, if it is occasional, can be observed without medication. 2, if frequent attacks, affecting normal life, you can use some medication, such as gabapentin, pregabalin, clonazepam and other drugs. The use of drugs need to pay attention to the adverse side effects of drugs, such as gabapentin common adverse reactions are dizziness, drowsiness, but patients can gradually tolerate. Pregabalin for renal function abnormalities need to be used with caution, clonazepam need to pay attention to the use of its drowsiness, as well as gait instability and other side effects, especially the use of elderly patients, need to pay attention to the possibility of transient mental anomalies, can be relieved after discontinuation of the drug. 3, some patients with cramps in the toes, is due to hypocalcemia caused by the calcium supplementation can be given to the treatment at this time.