Cephalosporin is a common antibiotic drug that has a therapeutic effect on digestive infections and respiratory infections. Smoking tobacco will contain a lot of nicotine and tar, these substances will affect the function of the digestive system, resulting in the digestive system to the components of the drug, can not be better absorbed and utilized, which will lead to the effect of the drug greatly reduced. And when smoking the body’s immunity will therefore be reduced, and therefore have an impact on the anti-infective effect of cephalosporin drugs. Cephalosporin is suitable for the treatment of respiratory diseases, and smoking will have a certain impact on the mucous membrane of the respiratory tract, and even lead to coughing, coughing up phlegm and other phenomena, which is not conducive to the recovery of the condition. When taking cephalosporins, it is best to try to quit smoking and drinking, and eat a light diet and rest properly to maximize the effect of the drug.