Certain hemostatic drugs, such as tranexamic acid, may cause elevation of plasma D-dimer and promote thrombosis. Plasma D-dimer is a fibrin degradation product that reflects the activity of the body’s fibrinolytic system. Elevated levels indicate hyperfibrinolysis or a state of hypercoagulability. It can be seen in diseases such as disseminated intravascular coagulation, pulmonary embolism, deep vein thrombosis, and malignant tumors. Tranexamic acid is a fibrinolytic enzyme inhibitor that inhibits fibrinogen activator so that fibrinogen cannot be converted to fibrinolytic enzymes, inhibiting fibrinolysis and producing hemostasis. Prolonged use or overdose may cause elevated plasma D-dimer and vascular thrombosis. Suspected drug-induced plasma D-dimer elevation, can promptly follow the doctor’s advice to stop the drug, seek medical attention to clarify the cause of the disease, the use of drugs need to be under the guidance of a professional doctor.