Usually, failure to lower blood glucose on Metformin alone requires enhanced dietary control, combined with exercise therapy, and changing or adding medications as prescribed by the doctor for relief. Patients should adopt a balanced diet with diversified food choices. To do staple food coarse food fine food with, side dishes meat and vegetarian with, not partiality, not picky about food. Promote small meals, regular meals. Advocate high dietary fiber diet, can be added to the meal every day oatmeal, cornmeal and other coarse grains, as well as kelp, konjac and fresh vegetables and other foods rich in dietary fiber. Exercise can increase insulin sensitivity and help control blood sugar and weight. Exercise is best done aerobically, gradually and over time. 150 minutes of moderate intensity exercise per week is recommended. If after the above treatment, the blood sugar still can’t come down, it is recommended to go to the regular hospital in time, and consult with the doctor whether it is necessary to change the drug or increase the dose of the drug and so on. In addition, it is recommended that patients who cannot lower their blood glucose on Metformin alone should follow the doctor’s instructions, and should not increase or decrease the dosage of the drug privately.