Immunohistochemistry for spindle cell tumors refers to further immunohistochemical testing to clarify classification and guide diagnosis and treatment. Spindle cell tumors are morphologically characterized tumor cells, which can be further classified as benign, malignant, and malignant with further refinement. This refinement needs to rely on immunohistochemistry to achieve a more accurate assessment, as well as to guide the choice of the next therapeutic option. Benign tumors do not require special treatment, while malignant spindle cell tumors require adjuvant therapy, such as chemotherapy or radiotherapy, depending on the size of the lesion and the extent of surgery. Therefore, immunohistochemistry can further clarify the diagnosis and treatment, as well as assess the prognosis.