Cranial bone is a very important bone in human body, if unfortunately defect occurs, it will bring a series of harm to human health. There are three common hazards of cranial defect, firstly, the asymmetry or collapse of the shape directly affects the aesthetics; secondly, the patient’s safety is greatly reduced, without the protection of the skull, the brain tissue is easily damaged by the outside world, making the situation worse; the cranial defect also leads to the instability of the intracranial environment, the cerebrospinal fluid circulation and blood circulation are affected. Therefore, patients are recommended to have skull repair surgery as soon as possible after skull defect. Although cranial defects need to be repaired as soon as possible, it is not advisable to do so too early or too late. The timing of cranial repair also needs to vary from person to person. For patients with open cranial comminuted fractures with relatively clean wounds and no cranial hypertension, it is recommended to perform cranioplasty in one stage; for patients with severe closed cranial injuries or cerebral hemorrhage, huge cranial defects caused by intracranial hypertension performed by decompression of the large bone flap, the general situation is performed after 3 months postoperatively. The current clinical introduction of advanced peek material, adding plastic concept, the peek cranial repair plastic surgery carried out, achieved ideal results. peek cranial repair plastic surgery advantages are mainly reflected in two aspects, one, peek material in elasticity, strength, insulation, stability and other aspects of performance are comparable to the human skull, is very ideal cranial repair material. Secondly, the personalized material edge groove design, unique thickness, and mesh design win better recovery for patients. After skull defect, after patients understand the hazards and benefits of repair after defect, the next concern is undoubtedly the cost. For this issue, there is no exact value, because each skull defect patient’s situation is different, and the specific needs to be determined based on the cost of repair materials, hospitalization, examination, surgery and other aspects of comprehensive assessment.