There are various reasons for uncomfortable and irritable legs at night. For example, after some women develop menopausal syndrome, they may show uncomfortable legs, irritability, excessive sweating, insomnia, and dreams at night while sleeping. This can be treated by taking medications that regulate menopausal syndrome and can help. The restlessness of the legs at night may be due to the weakness of the body and the symptoms of yin deficiency and fire exuberance. You can take six flavors of dihuang pill and other drugs for treatment, can play a good role in regulating. Sleeping at night with uncomfortable legs and irritability may also be the result of strenuous exercise during the day, after the leg muscles are strained. After a long time walking or strenuous exercise, the leg muscles will appear anaerobic fermentation phenomenon, which will make a large amount of lactic acid accumulation in the muscles, soreness, discomfort, irritability symptoms. Appropriate rest and activities can significantly alleviate this phenomenon.