IgA nephropathy grade III, if the treatment is timely, regular medication, the vast majority of patients can be controlled, but some patients can not be controlled, the prognosis is poor. IgA nephropathy is commonly used in Lee’s classification, grade III mainly suggests diffuse mesangial cell, mesangial stromal hyperplasia may be accompanied by glomerulosclerosis, a small amount of crescent formation can be seen, there is interstitial edema or tubular atrophy and so on. IgA nephropathy grade III can be controlled in most cases with timely treatment and regular medication. If the patient has frequent relapses or combines with underlying diseases such as hypertension and severe complications such as renal anemia, the disease will be poorly controlled, deteriorate rapidly and gradually develop to uremia stage. Patients with IgA Nephropathy Grade III should go to the hospital in time and receive standardized treatment under the guidance of professional physicians.