Renal insufficiency may cause a person to lose weight. Renal insufficiency is caused by a variety of etiological factors that lead to kidney function damage and result in symptoms such as proteinuria, swelling, nausea, vomiting, dizziness, and fatigue. Renal insufficiency can be categorized into acute renal insufficiency and chronic renal insufficiency, which is a renal impairment caused by various nephritis such as glomerulonephritis, pyelonephritis, nephrotic syndrome or systemic circulatory disorder or metabolic disorder. It can manifest as proteinuria, gastrointestinal symptoms such as nausea and vomiting, anorexia and abdominal distension, edema of both lower limbs or ankles, and even systemic metabolic toxicity. Due to persistent proteinuria, the important raw materials that make up muscles and bones are excreted from the body; coupled with nausea, vomiting, anorexia, etc., which affects digestion and absorption, resulting in gradual wasting of the patient’s body shape. Patients with renal insufficiency are recommended to consult regular hospitals and receive standardized treatment under the guidance of physicians.