Cirrhosis with splenomegaly and low platelet count, indicating liver cirrhosis, which triggers hypersplenism, may be viral hepatitis cirrhosis, alcoholic hepatitis cirrhosis, fatty liver cirrhosis, etc. Different treatments should be given according to the different platelet counts. 1. Diet therapy: when this situation occurs, first of all, according to the blood platelet count, to take the next step in the treatment program, if the platelet count is around 90, you can give appropriate food therapy to promote platelet production, such as peanut skin, is very beneficial to the recovery of platelets. 2. Medication: Generally, when the platelet count is above 50, medication can be used to promote platelet production, such as: recombinant human thrombopoietin injection, Ricocoon, aminopterin tablets, etc. 3. Platelet transfusion: When the platelet count is lower than 50, there may be the risk of internal bleeding, it is recommended to transfuse platelets, and at the same time, give medication for platelet generation. 4. Surgery: If hypersplenism is more obvious and platelet drop is also more obvious, surgery is recommended to remove the spleen. Cirrhosis with hypersplenism and low platelets, it is recommended to make corresponding treatment plan under the guidance of doctor according to the severity of the disease and the physical condition of the patient.