Bisphosphonates are mainly used in the treatment of some bone metastatic lesions to inhibit bone cell metastasis, that is, the role of bone protection, the most common zoledronic acid. If malignant tumors are found to have bone metastases, bone pain may occur in this place, and local osteoporosis is more serious, pathological fracture may occur, so it is necessary to apply bisphosphonates regularly to play the role of bone protection. Generally once a month, and then for severe osteoporosis, although there is no tumor, but also can consider using bisphosphonates, to anti-osteoporosis treatment. Generally, if the malignant tumor has bone metastasis, it suggests that it belongs to the progression of the disease, which is relatively advanced, but because the bone metastasis has not reached the vital organs, it will not endanger the life and health in the short term. Through the bisphosphonate drugs, as well as other radiation, chemotherapy and other integrated treatment, can still prolong the survival period.