Hand, foot and mouth disease is an acute infectious disease caused by a variety of intestinal viruses, which can be spread through close contact with people, air droplets, feces, saliva, herpes fluid, etc. Infants and children under 5 years of age are generally susceptible. Most children recover spontaneously in a week or so, but a few may suffer from complications such as myocarditis, pulmonary edema and aseptic meningoencephalitis, etc. Individuals with severe disease may develop rapidly and die. Therefore, parents should pay great attention to this disease. A. Early identification of HFMD The typical symptoms of HFMD are fever, loss of appetite, sore mouth, sore throat and discomfort, rash on the hands, feet, buttocks and other parts of the body, and herpes with pain in the mouth. The initial diagnosis of HFMD can be made if the child develops these symptoms during the epidemic season and after exposure to HFMD. At this time, parents can take their children to the hospital for the following tests to confirm the diagnosis of the disease: 1, nucleic acid testing: take a swab from the child’s mouth to do nucleic acid testing or stool to do nucleic acid testing to clarify the type of virus to confirm the diagnosis; 2, antibody testing: such as routine blood tests, antibodies to the common virus of hand, foot and mouth in the recovery period has a fourfold increase, then the diagnosis can be clear. Second, the differential diagnosis of hand, foot and mouth disease Hand, foot and mouth disease and herpes pharyngitis, papular urticaria, chickenpox similar, the onset of the disease should pay attention to the differential diagnosis, generally can be distinguished by the site of onset, the form of herpes and approach symptoms. The onset of hand, foot and mouth disease in the oral cavity, hands and feet, buttocks, herpes such as small rice grains or mung bean size, around the inflammatory red halo, less fluid in the blister, no pain, no itching, recovery without crusting and scarring, more anorexia, sore throat, fever and other symptoms; chicken pox throughout the body, mostly in the front chest and back, scalp, soles of the feet, fingers, palms can also be seen, the appearance of red pox rash the size of a grain of rice, in a few hours shaped like dew drops The rash is oval in shape, with a thin wall and easy to break, surrounded by a red halo and a characteristic “umbilical fossa” in the center, the child has no symptoms of sore throat, but the herpes has an itching sensation; papular urticaria mostly occurs on the trunk and extensor side of the limbs, the blisters are skin-colored or light red or light brown, varying in size, without a red halo around them, the itching is more obvious at night and affects the sleep of the child. After a clear diagnosis based on the above basis, the corresponding treatment should be given according to the condition.