Rabies is a lethal disease and has a near 100% fatality rate when it strikes. Prevention is important and there is no cure for rabies. Rabies is a zoonotic disease caused by rabies. Clinical manifestations for the characteristic fear of water, fear of wind, pharyngeal muscle spasm, progressive paralysis, etc., and finally involved in the heart and lungs leading to cardiopulmonary failure and death. Rabies is basically due to the fact that rabies vaccine is not injected in time after being bitten by a rabid dog. If the rabies vaccine is administered in a timely and correct manner after the bite, and if necessary, rabies immunoglobulin is injected, rabies basically will not occur. Although rabies is a fatal disease, it can still be prevented by rabies vaccine, and a good prevention can avoid rabies infection. The mortality rate after a rabies attack is close to 100%. Patients should treat their wounds promptly after rabies exposure and follow the doctor’s instructions for rabies vaccination.