The treatment of cholesterol and hyperlipidemia mainly includes medication, and plasma replacement therapy may be needed in rare cases. 1. Improve lifestyle: eat a light diet, avoid excessive greasy and high cholesterol foods, such as egg yolks, fried foods, animal offal, etc., and eat more vegetables and fruits. Quit smoking and drinking, appropriate aerobic exercise, such as tai chi, jogging, swimming, cycling, etc. can help improve lipid metabolism. 2. Drug therapy: Atorvastatin, Rosuvastatin and other statin drugs are commonly used to lower cholesterol, such as the combination of hypertriglyceridemia and poor control of statin drugs can be combined with fenofibrate, ezetimibe and other drugs. Those who still cannot reach the standard of lipid lowering or are intolerant can consider using PCSK9 inhibitors, such as eloxizumab or aliskirenzumab. 3. Other treatments: If the above treatments are not effective, plasma exchange therapy can be considered, but with the clinical application of PCSK9 inhibitors, it is less frequently used nowadays. If you find elevated lipids, please consult a doctor in time and follow the doctor’s instructions to standardize the treatment.