Breast nodules that are benign can be vaccinated with a booster shot; if they are malignant and undergoing radiotherapy, the vaccine should be avoided in the first place. Breast nodules are not a contraindication to booster vaccination, and there is no clinical evidence to prove a positive association between the new crown third injection and breast nodules, so patients with benign breast nodules can receive booster vaccination. Some patients who are taking medication can consult the vaccination unit first to confirm that the medication they are taking has no adverse effect on the vaccine before vaccination. For patients with malignant breast tumors who are currently receiving chemotherapy drugs, booster shots should be withheld to prevent adverse reactions to chemotherapy drugs or radiotherapy and other operations plus re-crown vaccine.