Patients with numbness of toes can have the following reasons: First, lumbar diseases: caused by lumbar disc herniation or lumbar spinal stenosis compressing the nerves, then numbness of the big toe and the second bunion can occur, and it is necessary to check the lumbar discs of CT, MRI for diagnosis and treatment. Second, peripheral neuropathy: it can be the peripheral neuropathy secondary to diabetes mellitus or caused by trauma, which should be diagnosed and treated according to the patient’s medical history and physical examination. Thirdly, tumor compression: Tumor compression around the nerves innervating the toes, or due to the growth of tumors on the nerves themselves can lead to numbness of the toes, which should be diagnosed and treated by physical examination and ultrasound, MRI and other tests.