Patients with advanced ovarian cancer may have pain symptoms, which are mainly related to cancer cells pressing or damaging surrounding tissues and organs. Ovarian cancer belongs to malignant tumors, and patients with the disease will experience discomfort symptoms such as abdominal distension, abdominal mass, abdominal pain and ascites. For patients with advanced ovarian cancer, pain may occur due to gradual enlargement of lesions and compression of surrounding organs, and some patients may also suffer from pain, cough, blood in stool, dizziness, vomiting and weight loss due to metastasis of cancer cells to surrounding tissues and other organs. In addition, when patients with advanced ovarian cancer undergo radiation therapy or chemotherapy, pain, hair loss, nausea and vomiting may occur due to damage of some normal cells. For pain caused by various circumstances, patients with advanced ovarian cancer can follow the doctor’s instruction to apply non-steroidal anti-inflammatory drugs such as indomethacin and aspirin to relieve the pain, and if the pain is severe, they can use opioid painkillers such as morphine. Daily can also listen to music, communicate with others and other ways to divert attention. It is suggested that patients diagnosed with ovarian cancer should actively cooperate with doctors in order to control the progress of the disease, improve the quality of life and prolong the survival time to a certain extent. The use of drugs should strictly follow the doctor’s prescription and should not be used blindly.