There is no such thing as the most effective antihypertensive drug, and it needs to be chosen according to the condition. Commonly used antihypertensive drugs include diuretics, calcium channel blockers, beta-blockers, ARB (angiotensin II receptor antagonists), ACEI (angiotensin converting enzyme inhibitors), such as hydrochlorothiazide, nifedipine, metoprolol, chlorosartan, captopril and so on. 1. Diuretic drugs: representative drugs include hydrochlorothiazide, etc., which are suitable for patients with simple systolic hypertension or hypertension in the elderly. Abnormal lipid metabolism, combined with renal insufficiency patients should be used with caution, gout patients are prohibited. 2. Calcium channel blocker drugs: the representative drugs are nifedipine and so on, which are suitable for the elderly hypertension and high systolic blood pressure hypertensive people. However, the early stage of drug treatment may cause increased heart rate, lower limb edema, etc. Patients with hepatic and renal insufficiency should be cautious. 3. β-blocker: representative drugs include metoprolol, etc. It is suitable for mild and moderate essential hypertension. The drug may make the symptoms of peripheral vascular circulatory disorders aggravated, severe renal impairment, cardiac insufficiency patients with caution, cardiogenic shock, sick sinus node syndrome or decompensated heart failure patients are prohibited. 4.ARB: Representative drugs are chlorosartan, etc., essential hypertension. It is characterized by long-lasting, smooth and highly effective antihypertensive effect. It is prohibited for pregnant women and those who are allergic to the drug. 5. ACEI: representative drugs have captopril, etc., applicable to patients with heart failure and diabetic nephropathy, and pay attention to hyperkalemia, pregnancy, renal artery stenosis patients are prohibited. It should be noted that different antihypertensive drugs have different contraindications and applicability, there is no suitable for all hypertensive patients with the most efficient drugs, patients need to be based on their own actual situation, under the guidance of the doctor to choose the right drug for treatment.