HPV vaccine for girls is recommended to be completed between the ages of 9-45 years old, and the earlier the vaccination time, the better the effect. HPV vaccine is divided into bivalent, quadrivalent and nine-valent, the difference between the three vaccines is mainly manifested in the prevention of different types of HPV viruses and different preventable diseases. The appropriate age for vaccination is 9-45 years old. It is recommended that women who meet the vaccination age complete the vaccination as early as possible. Nine-valent mainly targets HPV6, 11, 16, 18, 31, 45, 52 and 58 virus subtypes; four-valent mainly targets lower-risk virus HPV6 and 11, high-risk virus HPV16 and 18; and two-valent mainly targets high-risk virus HPV16 and 18. Nine-valent can prevent 90% of cervical cancer, vaginal cancer, vulvar cancer, anal cancer, precancerous lesions and other atypical lesions caused by HPV; four-valent can prevent cervical cancer, genital warts and so on; two-valent can mainly prevent cervical cancer. HPV vaccine is a prophylactic vaccine, which cannot treat infected HPV and related diseases, prevent all HPV types of infections, or stop HPV infections from progressing to disease progression. Therefore, regular cervical cancer screening is still needed after HPV vaccination.